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Dietary Intake of Magnesium or Calcium and Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients
Nutrients
2018 Mar 23;10(4):398. doi: 10.3390/nu10040398
Author
Evertine Wesselink , Renate M Winkels , Harm van Baar , Anne J M R Geijsen , Moniek van Zutphen , Henk K van Halteren , Bibi M E Hansson , Sandra A Radema , Johannes H W de Wilt , Ellen Kampman , Dieuwertje E G Kok
Author Information
1Division of Human Nutrition, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands; vera.wesselink@wur.nl (E.W.); renate.winkels@wur.nl (R.M.W.); harm.vanbaar@wur.nl (H.v.B.); anne.geijsen@wur.nl (A.J.M.R.G.); moniek.vanzutphen@wur.nl (M.v.Z.); ellen.kampman@wur.nl (E.K.)
2Department of Internal Medicine, Admiraal de Ruyter Ziekenhuis, ‘s-Gravenpolderseweg 114, 4462 RA Goes, The Netherlands; h.vanhalteren@adrz.nl
3Department of Surgery, Canisius Wilhelmina Ziekenhuis, Weg door het Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands; b.hansson@cwz.nl
4Department of Medical Oncology, Radboud University Medical Centre, Geert Grooteplein-Zuid 22, 6525 GA Nijmegen, The Netherlands; sandra.radema@radboudumc.nl
5Department of Surgery, Radboud University Medical Centre, Geert Grooteplein-Zuid 22, 6525 GA Nijmegen, The Netherlands; Hans.deWilt@radboudumc.nl
Correspondence: dieuwertje.kok@wur.nl;
Tel.: +31-317-485-901
Article notes
Copyright and License information
© 2018 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
PMC Copyright notice
PMCID: PMC5946183 PMID: 29570617
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe side-effect in colorectal cancer (CRC) patients. This study assessed the association between habitual dietary intake of magnesium or calcium and prevalence and severity of chronic CIPN in CRC patients receiving adjuvant chemotherapy. For this prospective cohort study, 196 CRC patients were considered. Magnesium and calcium intake was determined using a food frequency questionnaire at diagnosis, during and after chemotherapy. Chronic CIPN was assessed 12 months after diagnosis using the quality of life questionnaire CIPN20. Prevalence ratios were calculated to assess the association between magnesium or calcium intake and the prevalence of CIPN. Multivariable linear regression analysis was used to assess the association between magnesium or calcium intake and severity of CIPN. CIPN was reported by 160 (82%) patients. Magnesium intake during chemotherapy was statistically significantly associated with lower prevalence of CIPN (prevalence ratio (PR) 0.53, 95% confidence interval (CI) 0.32, 0.92). Furthermore, higher dietary intake of magnesium during (β −1.08, 95% CI −1.95, −0.22) and after chemotherapy (β −0.93, 95% CI −1.81, −0.06) was associated with less severe CIPN. No associations were found for calcium intake and the prevalence and severity of CIPN. To conclude, we observed an association between higher dietary magnesium intake and lower prevalence and severity of CIPN in CRC patients.
Keywords:
calcium, chemotherapy, colorectal cancer, magnesium, neuropathy, oxaliplatin