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The effect of perineural injection therapy on neuropathic pain: a retrospective study
J Dent Anesth Pain Med
2024 Feb 1;24(1):47–56. doi: 10.17245/jdapm.2024.24.1.47
Author
Haekyu Kim , Hyae Jin Kim , Young-Hoon Jung , Wangseok Do , Eun-Jung Kim
Author Information
1Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Busan, Republic of Korea.
2Department of Anesthesia and Pain Medicine, Biomedical research institute, Pusan National University Hospital, Busan, Republic of Korea.
3Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Yangsan, Republic of Korea.
✉Corresponding Author: Hyae Jin Kim, MD PhD. Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea. Tel: +82-51-240-7392, anekhj@gmail.com
✉Corresponding author.
Article notes
Received 2024 Jan 4; Revised 2024 Jan 16; Accepted 2024 Jan 24; Issue date 2024 Feb.
Copyright and License information
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
PMC Copyright notice
PMCID: PMC10864712 PMID: 38362256
Abstract
Background
Among the various pain-related diseases that can be encountered at the clinic, there is a neuropathic pain that is difficult to treat. Numerous methods have been proposed to treat neuropathic pain, such as taking medication, nerve block with lidocaine, or neurolysis with alcohol or phenol. Recently, a method of perineural injection using dextrose instead of lidocaine was proposed. This study was designed to compare the effects of perineural injection therapy (PIT) with buffered 5% dextrose or 0.5% lidocaine on neuropathic pain.
Methods
The data were collected from the database of pain clinic from August 1st, 2019 to December 31st, 2022 without any personal information. The inclusion criteria were patients diagnosed with postherpetic neuralgia (PHN), trigeminal neuralgia (TN), complex regional pain syndrome (CRPS), or peripheral neuropathy (PN), and patients who had undergone PIT with buffered 5% dextrose (Dextrose group) or 0.5% lidocaine (Lidocaine group) for pain control. The data of patients, namely sex, age, and pain score (numerical rating scale, NRS) were collected before PIT. The data of NRS, side effects, and satisfaction grade (excellent, good, fair, or poor) were collected one week after each of the four PIT, and two weeks after the last PIT.
Results
Overall, 112 subjects were enrolled. The Dextrose group included 89 and Lidocaine group included 23 patients. Because the number of patients in the Lidocaine group was too small to allow statistical analysis, the trend in Lidocaine group was just observed in each disease. There were no significant side effects except for a few bruise cases on the site of injection in all groups. The NRS in most Dextrose groups except CRPS were reduced significantly; however, the Lidocaine group showed a trend of pain reduction only in PHN. The Dextrose group except CRPS showed increased satisfaction two weeks after the final PIT.
Conclusion
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