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Effect of High-Power Laser Therapy on Modified Total Neuropathy Score in Patients with Chemotherapy Induced Peripheral Neuropathy

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Effect of High-Power Laser Therapy on Modified Total Neuropathy Score in Patients with Chemotherapy Induced Peripheral Neuropathy

Med. J. Cairo Univ
Vol. 88, No. 5, December: 2031-2035, 2020
Author
NOUR E. MOSTAFA, M.Sc. EMAN S. FAYEZ, Ph.D. HEBA A. KHALIFA, Ph.D. MOHAMED ABD ELRAHMAN HASSAN, M.D. and HEBA MOHAMED ABD ELSHAFI, Ph.D
Author Information

1The Department of Physical Therapy for Neuromuscular Disorders and its Surgery, Faculty of Physical Therapy and
The Department of Clinical Oncology, Faculty of Medicine, Cairo University

Abstract
Background

Peripheral neuropathy is a common problem among cancer patients receiving chemotherapy. ChemotherapyInduced Peripheral Neuropathy (CIPN) may have a significant negative impact on the Quality of Life (QOL) and treatment outcome. Studies showed that High Power Laser Therapy (HPLT) has an effect on peripheral neuropathy.

Aim of Study

To investigate the effect of high-power laser therapy on modified total neuropathy score in patients with chemotherapy induced peripheral neuropathy.

Patients and Methods

Thirty patients with CIPN, the patients were assigned randomly into two equal groups, study and control groups. The study group were received HPLT with routine medical treatment for 3 days/week for 6 weeks, the control group were received sham laser with routine medical treatment, CIPN was graded according to the modified Total Neuropathy Score (mTNS) to assess the severity of CIPN pre and post-treatment.

Results
There was significant decrease of the mean values of mTNS only on the study group. After HPLT, there was a significant decrease in the mean of neuropathy from 11.6±.96 before HPLT therapy to 7.8±1.26 after HPLT (p<0.0001). The mean difference was 3.26 and the percentage of change was 29.48 (p=0.0001).
Conclusion

The results suggest that the use of HPLT has a significant effect on mTNS in patients with CIPN.

Keywords:

Laser therapy – Chemotherapy-induced peripheral neuropathy – Cancer.