Info@NeuroCareUSA.com 918-359-3549

$45 Neuropathy Relief Package (reg. $450) > SCHEDULE NOW < Click Here to
$45 Neuropathy Relief Package (reg. $450) > SCHEDULE NOW < Click Here to
$45 Neuropathy Relief Package (reg. $450) > SCHEDULE NOW < Click Here to
$45 Neuropathy Relief Package (reg. $450) > SCHEDULE NOW < Click Here to

Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway

  • Home
  • Blogs
  • Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway

Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway

Am J Transl Res
2017 May 15;9(5):2629–2638.
Author
Yong-Da Liu, Zhi-Bin Wang , Guang Han , Ping Zhao
Author Information

1Department of Anesthesiology and Pain Management, Shengjing Hospital of China Medical University, Shenyang, China

✉Address correspondence to: Ping Zhao, Department of Anesthesiology and Pain Management, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning, China.
E-mail: zhaop@sj-hospital.org
Article notes

Received 2016 Dec 18; Accepted 2017 Apr 30; Collection date 2017.

Copyright and License information
AJTR Copyright © 2017

PMC Copyright notice

PMCID: PMC5446542 PMID: 28560010

Abstract
Peripheral neuropathic pain is a complex disease, and treated based on underlying diseases. Emerging evidences suggest that hyperbaric oxygen alleviates neuropathic pain. However, its cellular and molecular mechanism on pain relief is unknown. We hypothesize that hyperbaric oxygen alleviates neuropathic pain via activating autophagy flux and inhibiting mTOR pathway. Hyperbaric oxygen effectively inhibited nerve injury induced autophagy impairment and mTOR pathway activation in a rat spinal nerve ligation (SNL) model. Moreover, intrathecal injection of rapamycin, an autophagy inducer, enhanced hyperbaric oxygen effect by further decreasing mTOR activity. In contrast, chloroquine, an autophagy inhibitor, counteracted hyperbaric oxygen analgesic effect. These findings indicate that hyperbaric oxygen attenuated neuropathic pain by increasing spinal autophagic flux via inhibiting mTOR pathway. Our study provides pre-clinical evidences in expediting hyperbaric oxygen become a safe clinical treatment of neuropathic pain.
Keywords:
Spinal nerve ligation, neuropathic pain, autophagy, hyperbaric oxygen, chloroquine, mTOR
Click here for full article.

Integrative non-surgical neuromusculoskeletal care. Natural, effective pain solutions to help you restore to your peak performance. It’s time to take your life back and we’re here to help!

© 2024-2026 Neuro Care USA Nerve & Joint Centers.

TERMS & CONDITIONS | PRIVACY POLICY

Our website is for education and informational purposes only and is not intended as medical advice or a substitute for medical advice.  Articles on this website are provided for informational purposes only and Neuro Care USA Nerve & Joint Centers nor any of its affiliates make no claims of any guaranteed or proven therapeutic benefits or cures. Neuro Care USA Nerve & Joint Centers does not represent any device or device company. Neuro Care USA Nerve & Joint Centers is an independent company and the information on the website does not represent the voice or opinion of any device or device company nor the voice or opinion of any Provider. Providers are independent companies and do not represent the voice or opinion of Neuro Care USA Nerve & Joint Centers.  FTC 16 CFR Part 255 Compliance Statement: Results not typical. Any case studies, results, endorsements, or testimonials presented on this page reflect the personal experience and opinions of the individual patient and do not prove our treatment works. Therefore, you should not expect to have similar results, because every patient’s situation is unique.