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The potential positive effects of coenzyme Q10 on the regeneration of peripheral nerve injury
Explor Neuroprot Ther
2024;4:288–299
DOI: https://doi.org/10.37349/ent.2024.00083
Author
Ahmed Mead , Burcu Delibaş , Mehmet Emin Önger , Süleyman Kaplan
Received
January 01, 2024
Accepted
May 21, 2024
Published
June 21, 2024
Academic Editor
Lucio Marinelli, University of Genoa, Italy
Abstract
Peripheral nerve injuries (PNIs) constitute a significant concern as they predominantly affect young and productive age groups of the population, causing social and economic pressure on patients. PNIs are a global problem that can result in disability because of the disruption of nerve function. PNI leads to a reduction in nerve conduction velocity, which worsens or impairs the mobility of the innervated area. Managing PNI remains a major clinical challenge. Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant first identified in 1957. It is an important antioxidant necessary for the organs to maintain their normal function and the body’s chemical processes. It scavenges free radicals and reduces oxidative stress. Studies showed that antioxidants such as CoQ10 a potent antioxidant, help the regeneration of PNIs. It has been observed to increase the myelination process in nerve fibres and promote nerve regeneration in rats after injury. Therefore, this review handles the current positive effects of CoQ10 on peripheral nerve regeneration following injury.
Keywords:
Antioxidant, coenzyme Q10, mitochondria, peripheral nerve injury, rats